The graph below ranks each South Carolina County by total residents according to the 2006 census estimates.
South Carolina total population by county
| County | Total Population |
| Greenville |  417,166 |
| Richland | 348,226 |
| Charleston | 331,917 |
| Spartanburg | 271,087 |
| Lexington | 240,160 |
| Horry | 238,493 |
| York | 199,035 |
| Anderson | 177,963 |
| Berkeley | 152,282 |
| Aiken | 151,800 |
| Beaufort | 142,045 |
| Florence | 131,297 |
| Dorchester | 118,979 |
| Pickens | 114,446 |
| Sumter | 104,430 |
| Orangeburg | 90,845 |
| Oconee | 70,567 |
| Laurens | 70,374 |
| Greenwood | 68,213 |
| Darlington | 67,551 |
| Lancaster | 63,628 |
| Georgetown | 60,860 |
| Kershaw | 57,490 |
| Cherokee | 53,886 |
| Chesterfield | 43,191 |
| Colleton | 39,467 |
| Newberry | 37,762 |
| Williamsburg | 36,105 |
| Marion | 34,684 |
| Clarendon | 33,339 |
| Chester | 32,875 |
| Dillon | 30,984 |
| Marlboro | 29,152 |
| Union | 28,306 |
| Abbeville | 25,935 |
| Edgefield | 25,261 |
| Fairfield | 23,810 |
| Barnwell | 23,265 |
| Jasper | 21,809 |
| Hampton | 21,268 |
| Lee | 20,559 |
| Saluda | 19,059 |
| Bamberg | 15,678 |
| Calhoun | 15,026 |
| Allendale | 10,748 |
| McCormick | 10,226 |